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PubMed · 325834

Niridazole as an immunosuppressive agent.

J R Salaman·M Bird·A M Godfrey·B Jones·D Millar·J Miller
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Abstract

The immunosuppressive properties of niridazole, an antihelminthic drug, have been investigated in rats. When given orally at a dosage of 50 mg/kg it extended the median survival of cardiac allografts from 7 to 20 days. The immunosuppressive effect was not increased by giving either azathioprine or prednisolone concurrently, but when all three drugs were combined the immunosuppression was profound, and only 2 of 8 grafts were rejected. Drug combinations incorporating niridazole at a lower dosage or for a shorter period were less effective, and azathioprine and prednisolone on their own or together prolonged graft survival only marginally in this model.

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AnimalsGraft SurvivalHeart TransplantationImmunosuppressive AgentsMaleMyocardiumNiridazoleRatsSkin TransplantationTransplantation, HomologousJournal Article

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J R Salaman, M Bird, A M Godfrey, B Jones, D Millar, J Miller. 1977. Niridazole as an immunosuppressive agent.. https://pubmed.ncbi.nlm.nih.gov/325834/

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