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PubMed · 3260859

Effect of parathyroid function on serum bone Gla protein.

M Yoneda·K Takatsuki·K Yamauchi·Y Oiso·M Kurokawa·A Kawakubo·Y Torimoto·H Funahashi·A Tomita
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Abstract

The serum bone Gla protein (BGP) level was measured in patients with idiopathic hypoparathyroidism, and primary hyperparathyroidism, and normal volunteers. The mean serum BGP level was 4.5 +/- 0.20 micrograms/l in 40 normal volunteers. It was significantly lower in 12 patients with idiopathic hypoparathyroidism (1.6 +/- 0.21 micrograms/l, p less than 0.001) and significantly higher in 33 patients with primary hyperparathyroidism (13.0 +/- 1.3 micrograms/l, p less than 0.001). When a single intravenous injection of 30 micrograms of human PTH 1-34 was administered to the patients with idiopathic hypoparathyroidism, there was no significant change in serum BGP within the next 24 hours. Following a therapeutic oral dose of alfacalcidol, serum BGP was appreciably increased (p less than 0.001) from the preadministration value of 1.6 +/- 0.21 micrograms/l to 3.9 +/- 0.34 micrograms/l. In patients with primary hyperparathyroidism, the surgical excision of parathyroid adenoma led to a sharp decrease in serum PTH but a gradual decrease in serum BGP. The latter approximately paralleled the decline in serum alkaline phosphatase. Thus, serum BGP is a marker that reflects bone turnover status in parathyroid disease. It appears that the active form of vitamin D directly increases the secretion of BGP in existing osteoblasts and PTH mainly affects serum BGP to stimulate the bone remodeling cycles with its long term effect.

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AdenomaCalciumCalcium-Binding ProteinsFemaleFollow-Up StudiesHumansHydroxycholecalciferolsHyperparathyroidismHypoparathyroidismMaleOsteocalcinParathyroid GlandsParathyroid HormoneParathyroid NeoplasmsPeptide FragmentsTeriparatideTime FactorsComparative StudyJournal Article

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M Yoneda, K Takatsuki, K Yamauchi, Y Oiso, M Kurokawa, A Kawakubo, Y Torimoto, H Funahashi, A Tomita. 1988. Effect of parathyroid function on serum bone Gla protein.. https://doi.org/10.1507/endocrj1954.35.39

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