PubMed · 3276142
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E K Shultz, A R Schned, R I Rothstein. 1988. Sensitivity, specificity, and bias.. https://doi.org/10.1093/ajcp%2F89.1.137
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OBJECTIVES: To determine the type and frequency of thyroid disorders detected in infants with low thyroxine (T4) and nonelevated thyroid-stimulating hormone (TSH) screening test results in the Northwest Regional Newborn Screening Program (NWRNSP) over the 20-year period from May 1975 to May 1995 and to determine the effect of follow-up of these infants on the overall recall rate. STUDY DESIGN: The NWRNSP requests a serum specimen in infants with an absolute T4 level < 38.6 nmol/L (< 3 mg/dl) and in infants with two filter paper T4 concentrations less than the 3%, regardless of the TSH concentration. We conducted a retrospective analysis of infants who were followed up because of low T4 and nonelevated TSH concentrations on newborn screening. To determine the effect of follow-up of infants with low T4 levels, nonelevated TSH concentrations on the recall rate, we selected 1 year (1994) for review. Serum sample requests were evaluated to determine the reason for the request. RESULTS: Over this 20-year period, the NWRNSP detected 450 infants with primary hypothyroidism among 1,747,805 infants screened (1:3,884). Of these, 416 were detected on the basis of low T4 levels and nonelevated TSH screening test results, whereas an additional 34 infants with primary hypothyroidism and 29 infants with hypopituitary hypothyroidism were detected as a result of follow-up of low T4 levels and nonelevated TSH screening test results. This included 25 infants with delayed TSH rise (1:67,226), 9 infants with mild hypothyroidism (TSH levels < 25 mU/L) (1:194,212), 29 infants with hypopituitary hypothyroidism (1:60,269), and 434 infants with T4-binding globulin deficiency (1:4,027). Excluding those with T4-binding globulin deficiency, the false-positive rate was 43.5:1. This compares with an overall false-positive rate of 12:1 for our screening program. CONCLUSION: Follow-up of infants with low T4 and nonelevated TSH concentration on screening led to the detection of 63 additional infants with hypothyroidism, for an overall frequency of 1:27,743. We believe this yield justifies continued follow-up of infants with low T4 levels, nonelevated (TSH) screening test results in our program.
RATIONALE AND OBJECTIVES: The authors tested the hypothesis that satisfaction of search effect, which is associated with the failure to detect native chest abnormalities in the presence of simulated nodules, is caused by reduced gaze on the native abnormalities. MATERIALS AND METHODS: Gaze dwell time of 20 radiologists was recorded for the region around abnormalities on images. Ten radiographs were reviewed, nine of which contained native abnormalities. Each image was seen with and without a simulated nodule. RESULTS: The decrease in the rate of true-positive findings in the detection of native abnormalities on images that contained simulated nodules confirmed the occurrence of a satisfaction of search effect. Gaze times on native abnormalities (up to the time of report of the abnormalities) were the same for images with nodules in which native abnormalities were missed (gaze time, 9.4 seconds) as they were for images without nodules in which native abnormalities were detected (gaze time, 9.5 seconds). Gaze time on missed native abnormalities was not affected by the presence (7.80 seconds) or absence (7.45 seconds) of nodules. CONCLUSION: Reduction in gaze dwell time on the missed abnormalities is not the cause of satisfaction of search errors in chest radiographs.