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PubMed · 3278888

Corneal injuries.

D Lubeck·J S Greene
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Abstract

The article on corneal injuries illustrates the means by which mechanical, chemical, and radiant energies interrupt the normal anatomy and physiology of the cornea. Methods of diagnosis and management of such problems, including those caused by contact lenses, are presented.

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Burns, ChemicalContact LensesCorneal InjuriesEye BurnsEye InjuriesHumansMedical History TakingPhysical ExaminationRadiation InjuriesUltraviolet RaysWounds, PenetratingJournal ArticleReview

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D Lubeck, J S Greene. 1988. Corneal injuries.. https://pubmed.ncbi.nlm.nih.gov/3278888/

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Although the incidence of caustic ingestion is declining, the management of caustic esophageal strictures remains a challenge. Mitomycin C (MMC) inhibits fibroblast proliferation and is effective in reducing scar in animal experiments. We report the case of a child with a distal esophageal stricture from lye ingestion managed with MMC. Despite repeated dilatations, at 1 year post injury, the stricture was 20% of esophageal diameter. Mitomycin C (4 microg/mL) was applied topically and circumferentially by endoscopy and repeated 4 months later. At 20 months follow-up, the child eats normally, and esophagram showed decreased stenosis (stricture was 50% of esophageal diameter). No complications were observed. Although controlled trials are required to confirm its efficacy, MMC should be considered as an adjunct in the management of caustic esophageal strictures in children.

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