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PubMed · 3284357

Cell membrane in hypertension.

P Meyer·P Marche
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Abstract

Several alterations in membrane transport systems are observed in rat and human hypertension. Na+ flux changes are numerous, and cellular homeostasis to Na+ loading is impaired. Transmembrane Ca2+ movements are also numerous but clearly defined by a reduction in Ca2+ binders, a hypersensitivity of membrane phospholipase C, possible increased Ca2+ leak and reduced sensitivity of the Ca2+-pump to calmodulin. The resulting Ca2+ increase within arterial cells can be responsible for increased contractility and tone, leading to hypertension. These functional alterations in membrane transport can be secondary to a few well-defined membrane defects of genetic origin or to a diffuse structural perturbation in membranes involving lipid changes.

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AnimalsBiological TransportCalciumCell MembraneHumansHypertensionRatsRats, Inbred SHRSodiumJournal ArticleReview

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P Meyer, P Marche. 1988. Cell membrane in hypertension.. https://doi.org/10.1097/00000441-198804000-00029

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