Quantifying genotoxicity and non-genotoxicity.

H S Rosenkranz; F K Ennever

doi:10.1016/0165-1218(88)90009-2

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Quantifying genotoxicity and non-genotoxicity.

H S Rosenkranz·F K Ennever

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Abstract

Since the ability to induce genotoxicity is often equated with the potential for initiating the carcinogenic process, a method for quantitating genotoxicity would provide a useful measure for this potential. It is demonstrated herein that CPBS, the Carcinogenicity Prediction and Battery Selection method, provides a useful quantitative measure of genotoxicity as well as allowing for the detailed evaluation of the performance of batteries of short-term tests in order to select those predictive of carcinogenic potential.

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Animals Carcinogens Cell Transformation, Neoplastic Chromosome Aberrations DNA Damage DNA Repair In Vitro Techniques Mutagenicity Tests Mutagens Probability Salmonella typhimurium Sister Chromatid Exchange Time Factors Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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H S Rosenkranz, F K Ennever. Quantifying genotoxicity and non-genotoxicity.. https://doi.org/10.1016/0165-1218(88)90009-2

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