PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 3287238

Cyclo(His-Pro): its distribution, origin and function in the human.

C Prasad
View original source ↗Export metadata ↓

Abstract

Cyclo(His-Pro), or histidyl-proline diketopiperazine, is a cyclic dipeptide endogenous to blood, cerebrospinal fluid (CSF), semen, brain, spinal cord, and gastrointestinal tract of humans. Although a part of cyclo(His-Pro) clearly appears to be derived from the limited proteolysis of thyrotropin-releasing hormone by Pyroglutamate aminopeptidase, the biosynthetic origin of the remainder of the peptide can only be speculated. The levels of this peptide in blood and CSF fluctuate in health and disease in a manner appropriate for a physiologically active endogenous molecule.

Explore related subjects

Central Nervous SystemDigestive SystemHumansOrgan SpecificityPeptides, CyclicPiperazinesJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

C Prasad. 1988. Cyclo(His-Pro): its distribution, origin and function in the human.. https://doi.org/10.1016/s0149-7634(88)80069-1

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome.

Restless legs syndrome (RLS) can occur as a primary disorder, with no apparent cause other than a possible genetic predisposition, or as a secondary condition, most commonly related to iron deficiency, pregnancy, or end-stage renal disease. Recent studies have identified 2 different phenotypes of RLS based on age at onset of symptoms. Persons whose RLS symptoms start at an earlier age (<45 years) are more likely to have a family history of RLS and tend to have a more slowly progressive development of the disorder compared with individuals who have later onset of symptoms. In the past, our ability to determine either prevalence or population factors associated with increased occurrence of RLS has been limited. However, 4 different diagnostic criteria have been established. Familiarity with diagnostic criteria and clinical characteristics are essential for diagnosis and appropriate treatment, if required.

Central Nervous System↗