Controversies in antimicrobial prophylaxis.

J V Hirschmann

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PubMed · 3301017

Controversies in antimicrobial prophylaxis.

J V Hirschmann

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Abstract

This paper examines four controversies in antimicrobial prophylaxis. Duration of prophylaxis: Antimicrobial agents must be present in the tissues throughout the operation. Usually, a single preoperative or intraoperative dose will suffice; postoperative doses are unnecessary. Third-generation cephalosporins: no clinical evidence supports their use for surgical prophylaxis. Optimal prophylaxis for colorectal surgery: the information is conflicting, but oral agents combined with a parenteral antibiotic may be optimal. Prophylaxis for patients with indwelling prosthetic joints or vascular grafts: prophylaxis is unnecessary for procedures like dental work that cause transient bacteremia, but established infections should receive prompt, vigorous antimicrobial therapy.

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Animals Anti-Bacterial Agents Blood Vessel Prosthesis Cephalosporins Colon Drug Administration Schedule Humans Joint Prosthesis Premedication Rectum Sepsis Surgical Wound Infection Journal Article Review

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J V Hirschmann. 1987. Controversies in antimicrobial prophylaxis.. https://pubmed.ncbi.nlm.nih.gov/3301017/

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