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PubMed · 3304060

Interaction of ascorbate and alpha-tocopherol.

E Niki
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Abstract

Vitamins C and E function as water-soluble and lipid-soluble chain-breaking antioxidants, respectively, and protect lipids, proteins, and membranes from oxidative damage. Vitamin C scavenges oxygen radicals in the aqueous phase, whereas vitamin E scavenges oxygen radicals within the membranes. Vitamin C regenerates vitamin E by reducing vitamin E radicals formed when vitamin E scavenges the oxygen radicals. This interaction between vitamin C and vitamin E radicals can take place not only in homogeneous solutions but also in liposomal membrane systems where vitamins C and E reside separately outside and within the membranes respectively, and vitamin C can act as a synergist.

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AntioxidantsAscorbic AcidCell MembraneDrug SynergismFatty Acids, UnsaturatedFood PreservativesFree RadicalsLipid PeroxidesOxidation-ReductionOxygenVitamin EJournal ArticleReview

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E Niki. 1987. Interaction of ascorbate and alpha-tocopherol.. https://doi.org/10.1111/j.1749-6632.1987.tb23761.x

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