Reparative processes in aged brain.

G Calderini; F Bellini; A Consolazione; R Dal Toso; F Milan; G Toffano

doi:10.1159/000212882

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Reparative processes in aged brain.

G Calderini·F Bellini·A Consolazione·R Dal Toso·F Milan·G Toffano

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Abstract

Endogenous neurotrophic factors have been proposed to play an important role in degenerative diseases and aging. In aged rats, neurotrophic activity induced by partial lesion of nigro-striatal pathways seems to be lower compared to young rats when assayed in vitro on cultured mesencephalic dissociated neuronal cells. In parallel experiments, we could also observe an age-dependent delay in spontaneous recovery of striatal tyrosine hydroxylase activity after lesion. Both experimental evidences suggest a low-potential neuroplasticity in aged rats. Nevertheless, the aging brain seems to be responsive to pharmacological manipulation. Long-term phosphatidylserine treatment has been shown to maintain the integrity of neuronal structures altered by the aging process. Putative mechanisms of action underlying these effects are presented.

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G Calderini, F Bellini, A Consolazione, R Dal Toso, F Milan, G Toffano. 1987. Reparative processes in aged brain.. https://doi.org/10.1159/000212882

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