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[Chromosome aberrations and malignant lymphomas].

C Fonatsch·G Gradl
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Abstract

Chromosomal findings in malignant lymphomas are correlated to the histopathology and the immunologic phenotype of lymphoma subgroups. The prognostic significance of a cytogenetic analysis and its value for therapy planning are discussed. With respect to tumorigenesis it is emphasized that a number of proto-oncogenes and genes for cell differentiation, such as immunoglobulin and T-cell receptor genes, have been localized at sites of recurring chromosomal rearrangements. One chapter deals with cytogenetic data in correlation to findings of DNA recombination studies in Hodgkin's disease.

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Chromosome AberrationsHodgkin DiseaseHumansLymphoma, Non-HodgkinPrognosisProto-OncogenesEnglish AbstractJournal ArticleResearch Support, Non-U.S. Gov'tReview

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C Fonatsch, G Gradl. 1987. [Chromosome aberrations and malignant lymphomas].. https://doi.org/10.1159/000216408

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