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PubMed · 3317827

The chicken B cell compartment.

J C Weill·C A Reynaud
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Abstract

A very unusual molecular mechanism is involved in generating the preimmune repertoire in the chicken bursa of Fabricius. A unique rearranged V gene is diversified through a program of segmental gene conversion with a pool of noncoding pseudogenes being used as donors. A specifically committed progenitor that originates in the embryonic bursa is responsible for long-term maintenance of the B cell population. Both these properties and the characteristics of the peripheral B cell compartment are discussed in terms of the evolution of the T and B immune systems.

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AnimalsAntibody DiversityB-LymphocytesBursa of FabriciusChickensGenes, ImmunoglobulinImmunoglobulin Variable RegionImmunoglobulinsJournal ArticleReview

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J C Weill, C A Reynaud. 1987-11-20. The chicken B cell compartment.. https://doi.org/10.1126/science.3317827

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