Interleukin 1 affects glucose homeostasis.

A del Rey; H Besedovsky

doi:10.1152/ajpregu.1987.253.5.r794

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PubMed · 3318508

Interleukin 1 affects glucose homeostasis.

A del Rey·H Besedovsky

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Abstract

Alterations in glucose metabolism are known to occur during certain types of inflammation and infectious diseases. Interleukin 1 (IL 1), an immune-derived cytokine released during these processes, is proposed to function as a mediator of such alterations, since administration of low subpyrogenic doses of human rIL 1 to mice and rats produced hypoglycemia. In mice this effect was paralleled by increased insulin, glucagon, and corticosterone blood levels. When IL 1 was repeatedly injected, mice remained hypoglycemic for at least 14 h after the last injection. Furthermore, these animals responded normally to a challenge with glucose, thus suggesting that the proper function of the pancreas was preserved. A moderate hypoglycemia, paralleled by increased glucagon and corticosterone blood levels, was also observed in IL 1-injected rats, but no increase in insulin levels was detected. IL 1 administration to adrenalectomized rats resulted in a more marked hypoglycemia and in a profound hypoinsulinemia. The results suggest that IL 1 causes hypoglycemia by increasing insulin blood levels and probably also by mechanisms independent of the insulin secretagogue action of this cytokine.

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Adrenalectomy Animals Blood Glucose Corticosterone Glucagon Glucose Homeostasis Insulin Interleukin-1 Male Mice Mice, Inbred C3H Journal Article Research Support, Non-U.S. Gov't

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A del Rey, H Besedovsky. 1987. Interleukin 1 affects glucose homeostasis.. https://doi.org/10.1152/ajpregu.1987.253.5.r794

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