Antithrombogenic heparin-bound polyurethanes.

Y Ito

doi:10.1177/088532828700200204

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Antithrombogenic heparin-bound polyurethanes.

Y Ito

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Abstract

Many kinds of heparin-bound polyurethanes have been developed. Polyurethanes are a family of elastomers displaying better blood-compatibility than other polymeric materials. It is useful to modify this material by heparinization. Several approaches to heparinization have been devised: 1) a general method of heparinization, applicable to all polymeric materials, 2) a heparinization method specific to polyurethanes, and 3) the design of heparinizable polyurethane derivatives. These three approaches are first explained in detail. Then, the antithrombogenic mechanism of the heparinized polymers is discussed. Finally, the interactions of the heparinized polymers with blood coagulation factors, plasma proteins, and platelets are discussed.

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Biocompatible Materials Blood Vessel Prosthesis Chemical Phenomena Chemistry Graft Occlusion, Vascular Heparin Humans Materials Testing Polyurethanes Journal Article Research Support, Non-U.S. Gov't Review

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Y Ito. 1987. Antithrombogenic heparin-bound polyurethanes.. https://doi.org/10.1177/088532828700200204

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