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PubMed · 3333332

Massive transfusion.

R Rutledge·G F Sheldon·M L Collins
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Abstract

Massive transfusion is a potentially serious problem associated with a number of complications, including changes in coagulation factor and platelet concentration, nonmechanical bleeding, hypothermia, pulmonary dysfunction, hypokalemia and hyperkalemia, hypocalcemia, hypomagnesemia, acidosis and alkalosis, immune suppression, blood transfusion reactions, and transmission of infectious diseases. The pathophysiology and management of massive transfusion are reviewed in this article.

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Blood Coagulation DisordersBlood Coagulation FactorsBlood Platelet DisordersBlood TransfusionHumansTransfusion ReactionJournal ArticleReview

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R Rutledge, G F Sheldon, M L Collins. 1986. Massive transfusion.. https://pubmed.ncbi.nlm.nih.gov/3333332/

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[Hemostatic anomalies and coronary risk].

The main role of thrombosis in the acute coronary event is now well documented. Numerous hemostatic factors are involved in thrombosis. Among them, fibrinogen, factor VII, leucocytes and platelets have been shown by epidemiology, to be closely related to the acute coronary event. The key role seems to be reserved to platelets since the close relationship of their activity as evaluated by platelet aggregation tests, to both coronary episodes and the main risk factors such as smoking, diabetes and dietary habits, has been recently demonstrated. In addition, the role of platelets has been confirmed by the marked protective effect against coronary events, of drugs such as aspirin, inhibiting platelet aggregation.

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