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d-Amphetamine binding to brain lipid.

M A Goldberg·T Todoroff
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Abstract

The interaction of d-amphetamine with several brain tissue components has been investigated. A brain lipid extract and a number of individual phospholipids were found to bind d-amphetamine when measured by means of a hexane-buffer partition coefficient technique. Phosphatidylserine showed the greatest binding and phosphatidylethanolamine and dipalmitoyllecithin were also effective. Phospholipid binding of d-amphetamine was shown to be related to fatty acid composition. Cholesterol and ganglioside did not bind. It is suggested that phospholipid binding of d-amphetamine may play a role in the pharmacological action of this drug.

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AnimalsBrainCattleDextroamphetamineHydrogen-Ion ConcentrationMembrane LipidsModels, ChemicalPhospholipidsSolubilityStructure-Activity RelationshipJournal Article

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M A Goldberg, T Todoroff. 1978. d-Amphetamine binding to brain lipid.. https://doi.org/10.1007/bf00965999

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