PubMed · 3351521
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
R Duncan. 1988. Local autonomic failure affecting a limb.. https://doi.org/10.1136/jnnp.51.1.157
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
To study the mechanism underlying trans-synaptic neuropeptide regulation, mRNA levels of neuropeptide Y were examined in the rat stellate and superior cervical ganglia using a specific neuropeptide Y cRNA probe. Basal levels of neuropeptide Y mRNA were detectable in total RNA extracts from single ganglia. Reserpine induced a large rise in ganglion neuropeptide Y mRNA. Decentralization prevented the increase of neuropeptide Y mRNA content in the ganglia. This suggests that the reserpine induced increase in neuropeptide Y mRNA was dependent on transsynaptic stimulation. Consequently, neuropeptide mRNA levels in sympathetic ganglia may be under the control of preganglionic impulse flow.
The early events in the development of the heart ganglia and nerves in human fetuses ranging from 5 to 12 weeks of gestation age were studied by transmission electron microscopy. The first neuroblasts in the atrial mesenchyme differ from surrounding cells in the presence of short cisternae of rough endoplasmic reticulum and in the absence of glycogen particles. The most valuable criterion for identification of neuroblasts is the presence of contacts with preganglionic nerve terminals. Only ganglia composed of compact aggregations of neuronal cells and nerve terminals have a complete glial sheath. The first signs of synapse formation were seen in 5-week-old fetuses; well developed synapses with many synaptic vesicles were found from the 8th week of gestation onwards. These were predominantly axodendritic synapses. It is proposed that synaptogenesis begins with the appearance of osmiophilic zones at the sites of interneuronal contacts, then synaptic vesicles move by axonal transport to reach the preformed specialized junctions and stop in axonal presynaptic varicosities.