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PubMed · 335513

Diffuse intravascular coagulation in liver disease?

P W Straub
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Abstract

The evidence for intravascular coagulation in liver diseases is critically reviewed. Alternative mechanisms for hypofibrinogenemia and the accelerated disappearance of fibrinogen from blood are proposed, such as loss into extravascular compartments (e.g., ascites, areas of liver necrosis, etc.). Possible mechanisms other than DIC for the elevation of serum FDP are also considered, such as extravascular fibrinogen proteolysis with subsequent transfer of FDP to blood. Therapy is discussed with reference to the current knowledge on pathophysiology of the coagulation defect in liver diseases.

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AfibrinogenemiaBlood Cell CountBlood PlateletsDisseminated Intravascular CoagulationFactor V DeficiencyFibrinFibrin Fibrinogen Degradation ProductsFibrinogenHalf-LifeHemophilia AHeparinHumansLiver DiseasesPeptide HydrolasesThrombocytopeniaThrombosisJournal ArticleReview

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BibTeXRIS

P W Straub. 1977. Diffuse intravascular coagulation in liver disease?. https://doi.org/10.1055/s-0028-1087126

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Afibrinogenemia↗