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Planning the suicide experiments.

S Hazout·A J Valleron
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Abstract

Suicide experiments involve a great degree of uncertainty in the counting of cell colonies. This work studies from a statistical point of view the precision of the estimation as a function of the number of experimental units which are used. Assuming that the colony numbers in recipients follow a Poisson distribution, we give the necessary number of recipients (a) to determine with a given accuracy the percentage of DNA synthesizing cells (S cells), (b) to test whether or not a cell population is quiescent, and (c) to compare the percentages of S cells in two cell populations.

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AnimalsBone Marrow CellsBone Marrow TransplantationCell CycleCell SurvivalCulture TechniquesCytological TechniquesDNADNA, NeoplasmMiceNeoplasms, ExperimentalProbabilitySpleenJournal Article

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S Hazout, A J Valleron. 1977. Planning the suicide experiments.. https://doi.org/10.1111/j.1365-2184.1977.tb00313.x

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