Bacterial radiosensitization by 8-methoxypsoralen.

J L Redpath; M L Tortorello

doi:10.1080/09553007714551221

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Bacterial radiosensitization by 8-methoxypsoralen.

J L Redpath·M L Tortorello

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Abstract

8-Methoxypsoralen has been shown to act as a radiosensitizer of hypoxic bacterial cells with uvrA, recA and uvrB and/or lexA mutations. No effect of the drug on the radiosensitivity of oxic bacteria with these mutations was observed. This drug differs from O2 and electron-affinic radiosensitizers in that its effect is not purely dose-modifying and can exceed the oxygen effect in certain mutants.

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Dose-Response Relationship, Radiation Electrons Escherichia coli Methoxsalen Mutation Oxygen Radiation Tolerance Radiation-Sensitizing Agents Journal Article Research Support, U.S. Gov't, P.H.S.

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J L Redpath, M L Tortorello. 1977. Bacterial radiosensitization by 8-methoxypsoralen.. https://doi.org/10.1080/09553007714551221

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