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LSD: permanent behavioral effect in rats.

P B Silverman
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Abstract

Rats with a unilateral nigrostriatal lesion produced by infusion of 6-hydroxydopamine (6-OHDA) exhibited acute contralateral (apomorphine-like) rotation in response to systemic LSD administration. When re-introduced to the environment in which LSD had been administered weeks earlier, the animals exhibited a 2-3 min burst of contralateral rotation. This behavior developed over a period of weeks and could be produced by a single LSD treatment. This latent, undrugged rotation is similar to that which we previously reported to result from one or more apomorphine treatments.

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AnimalsApomorphineLysergic Acid DiethylamideMaleRatsRats, Inbred StrainsRotationStereotyped BehaviorJournal Article

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P B Silverman. 1988-03-01. LSD: permanent behavioral effect in rats.. https://doi.org/10.1016/0014-2999(88)90794-7

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