A molecular basis for MHC class II--associated autoimmunity.

J A Todd; H Acha-Orbea; J I Bell; N Chao; Z Fronek; C O Jacob; M McDermott; A A Sinha; L Timmerman; L Steinman

doi:10.1126/science.3368786

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PubMed · 3368786

A molecular basis for MHC class II--associated autoimmunity.

J A Todd·H Acha-Orbea·J I Bell·N Chao·Z Fronek·C O Jacob·M McDermott·A A Sinha·L Timmerman·L Steinman

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Abstract

Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T cells). Nucleotide sequence polymorphism in the genes that encode the class II MHC products determines the specificity of the immune response and is correlated with the development of autoimmune diseases. This study identifies certain class II polymorphic amino acid residues that are strongly associated with susceptibility to insulin-dependent diabetes mellitus, rheumatoid arthritis, and pemphigus vulgaris. These findings implicate particular class II MHC isotypes in susceptibility to each disease and suggest new prophylactic and therapeutic strategies.

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Amino Acid Sequence Arthritis, Rheumatoid Autoantibodies Autoimmune Diseases Diabetes Mellitus, Type 1 HLA-D Antigens Humans Major Histocompatibility Complex Molecular Sequence Data Pemphigus Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J A Todd, H Acha-Orbea, J I Bell, N Chao, Z Fronek, C O Jacob, M McDermott, A A Sinha, L Timmerman, L Steinman. 1988-05-20. A molecular basis for MHC class II--associated autoimmunity.. https://doi.org/10.1126/science.3368786

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