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PubMed · 3378374

Circumscribed dermal melanoses. Classification and histologic features.

Y Hori·O Takayama
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Abstract

Dermal melanosis is caused by deposition of melanin in melanophages or by free melanin in the dermis or in dermal melanocytes. Circumscribed dermal melanoses can be congenital or acquired and at times are nevoid in distribution. Bilateral nevus of Ota-like lesions and blue macules recently have been described in association with progressive systemic sclerosis. Macular amyloidosis and friction melanosis are also acquired dermal melanoses. It is important to distinguish dermal melanoses caused by the presence of melanocytes in the dermis from those produced by the presence of melanin free within the dermis. Clinically, the two different processes may have very similar appearances. Treatments for circumscribed dermal melanoses include cosmetics, cryotherapy, dermabrasion, or, rarely, skin grafts.

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AmyloidosisHumansIncontinentia PigmentiMelanosisNevus of OtaNevus, PigmentedSkin DiseasesSkin NeoplasmsJournal Article

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Y Hori, O Takayama. 1988. Circumscribed dermal melanoses. Classification and histologic features.. https://pubmed.ncbi.nlm.nih.gov/3378374/

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Schistosoma-induced amyloidosis in hamsters is gender-dependent.

BACKGROUND: A high serum level of female protein (FP), found to be a constituent of Syrian hamster amyloid was associated with enhanced amyloidosis. In this work, we studied the sex-limited factors in the induction of amyloidosis in Syrian hamsters infected with either Schistosoma mansoni or S. hematobium cercariae. METHODS: Hamsters were infected with different species of schistosome cercariae and sacrificed after different time periods of infection. Kidney and liver specimens were processed in paraffin, stained with Congo-red and examined by ordinary light and polarized light microscopy. RESULTS: Statistical analysis showed a significant difference in intensity of kidney and liver amyloid deposits (P<0.002 & <0.007 respectively) between females and male hamsters with extensive deposits in the former. Amyloid deposits were correlated significantly to the duration of infection (P<0.001) than the load of worm recovered. CONCLUSION: From this study, we conclude that, in hamster model, Schistosoma-induced amyloidosis is enhanced in females than male hamsters. This may be due to the high serum level of FP that is normally detected in females. As an experimental model for schistosomal nephropathy, we recommend to use male hamsters instead of females to minimize the effect of amyloid deposits, which may mask other pathological changes associated with schistosomal infection.

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