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PubMed · 3378654

HLA and multiple skin carcinomas.

D Cerimele·L Contu·C Carcassi·G Costa·G La Nasa·E Sanna·G V Campus
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Abstract

The presence of HLA-associated genetic factors in patients with multiple skin carcinomas was investigated. 43 patients affected by multiple basal and squamous cell carcinomas and 220 healthy age-matched controls were typed for 72 HLA-A, B, C, DR antigens. A negative association of B-17 (mostly B-58) and a positive association of Cw-3 and DR-1 was observed in patients with multiple basal cell carcinomas; a similar negative association with B-58 and positive association with DR-1 was seen in patients with squamous cell carcinomas. The results of this study suggest the presence of resistance factors to the development of skin cancers associated with B-17 (B-58) antigen.

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Basal Cell CarcinomaCarcinoma, Squamous CellHLA AntigensHLA-D AntigensHLA-DR AntigensHumansSkin NeoplasmsJournal Article

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D Cerimele, L Contu, C Carcassi, G Costa, G La Nasa, E Sanna, G V Campus. 1988. HLA and multiple skin carcinomas.. https://doi.org/10.1159/000248700

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