Variations in c-fos gene expression during rat brain development.

R M Gubits; J L Hazelton; R Simantov

doi:10.1016/0169-328x(88)90067-8

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Variations in c-fos gene expression during rat brain development.

R M Gubits·J L Hazelton·R Simantov

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Abstract

Expression of the c-fos proto-oncogene has been associated with mitosis or differentiation in a number of tissue culture model systems. We have studied the expression of this gene during in vivo brain development in the rat. Our results demonstrate that very low levels of c-fos mRNA are detectable during the period of development characterized by rapid mitosis, whereas much higher concentrations of c-fos mRNA are found in the brains of older neonatal animals and adults. Therefore, although c-fos could be participating in the regulation of mitosis during early postnatal development of the brain, it is also likely to play an important role in mature brain tissue.

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Aging Animals Brain Electric Conductivity Embryonic and Fetal Development Organ Specificity Proto-Oncogenes RNA, Messenger Rats Rats, Inbred Strains Synapses Transcription, Genetic Journal Article Research Support, U.S. Gov't, P.H.S.

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R M Gubits, J L Hazelton, R Simantov. 1988. Variations in c-fos gene expression during rat brain development.. https://doi.org/10.1016/0169-328x(88)90067-8

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