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Prostatic carcinogenesis evoked by cellular interaction.

L W Chung·S M Chang·C Bell·H Zhau·J Y Ro·A C von Eschenbach
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Abstract

Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.

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AndrogensAnimalsDihydrotestosteroneDisease Models, AnimalEpitheliumFibroblastsMaleNeoplasms, Hormone-DependentProstatic NeoplasmsRatsTumor Cells, CulturedJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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L W Chung, S M Chang, C Bell, H Zhau, J Y Ro, A C von Eschenbach. 1988. Prostatic carcinogenesis evoked by cellular interaction.. https://doi.org/10.1289/ehp.887723

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