Structure-distribution studies on some 99mTc-o-hydroxybenzyliminodiacetic acid complexes.

D J Maddalena; G M Snowdon; J G Wilson

doi:10.1016/0883-2897(88)90113-4

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Structure-distribution studies on some 99mTc-o-hydroxybenzyliminodiacetic acid complexes.

D J Maddalena·G M Snowdon·J G Wilson

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Abstract

Biodistributions of a series of thirteen 99mTc-o-hydroxy-benzyliminodiacetic acid complexes were carried out in rats and their hepatobiliary and urinary outputs correlated with lipophilicity, molecular weight, influence of substituent and plasma protein binding. Hepatobiliary output was moderate for those ligands with large alkyl substituents [t-butyl (36%), and iso-octyl (42%)] but compared to HIDA compounds was relatively low, indicating that they would not be suitable for clinical use. Halogen substituents had only a small effect on increasing hepatobiliary output but a large effect on reducing the urinary clearance.

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Animals Female Imino Acids Organometallic Compounds Organotechnetium Compounds Rats Structure-Activity Relationship Technetium Tissue Distribution Journal Article

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D J Maddalena, G M Snowdon, J G Wilson. 1988. Structure-distribution studies on some 99mTc-o-hydroxybenzyliminodiacetic acid complexes.. https://doi.org/10.1016/0883-2897(88)90113-4

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