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Ethanol increases synaptosomal free calcium concentration.

M Davidson·P Wilce·B Shanley
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Abstract

The effect of ethanol on synaptosomal free calcium concentration [( Ca2+]i) and 45Ca2+ uptake was studied in vitro. Synaptosomes were prepared from forebrains of adult rats and incubated in the presence of ethanol 50-500 mM. [Ca2+]i determined by means of the Ca2+-sensitive dye, fura-2, was increased by ethanol in polarized and depolarized synaptosomes, whereas 45Ca2+ uptake was decreased. The results suggest that ethanol may influence neuronal calcium homeostasis by increasing rather than decreasing [Ca2+]i.

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AnimalsCalciumEthanolMaleRatsRats, Inbred StrainsSynaptosomesJournal Article

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M Davidson, P Wilce, B Shanley. 1988-06-29. Ethanol increases synaptosomal free calcium concentration.. https://doi.org/10.1016/0304-3940(88)90375-8

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