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[Studies on cardiac principle in Aconite roots. I. Isolation and structural determination of higenamine (author's transl)].

T Kosuge·M Yokota·M Nagasawa
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T Kosuge, M Yokota, M Nagasawa. 1978. [Studies on cardiac principle in Aconite roots. I. Isolation and structural determination of higenamine (author's transl)].. https://doi.org/10.1248/yakushi1947.98.10_1370

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In vitro modulation of CNS beta-receptor number by antidepressants and beta-agonists.

In vitro incubation of rat cerebral cortex slices with antidepressant drugs reduced beta-adrenergic receptor binding of 3H-dihydroalprenolol by 30%. The decrease was maximum after 60 min, and was reversible after 120 min. (-)-Isoproterenol incubation caused a rapid and reversible loss (60%) of beta-receptor binding. Both effects were due to a decrease in beta-receptor sites. In vitro beta-receptor subsensitivity due to desipramine and isoproterenol was non-additive. The observed reversible loss of beta-receptor sites may be an initial phase of the beta-receptor down-regulation by antidepressants seen in vivo.

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