Pyroglutamic acid improves learning and memory capacities in old rats.

F Drago; C Valerio; V D'Agata; C Astuto; F Spadaro; G Continella; U Scapagnini

PubMed · 3402813

Pyroglutamic acid improves learning and memory capacities in old rats.

F Drago·C Valerio·V D'Agata·C Astuto·F Spadaro·G Continella·U Scapagnini

Abstract

The effects of the arginine salt of pyroglutamic acid (2-oxo-pyrrolidone carboxylic acid, PCA) on learning and memory capacities of old rats were studied in a subchronic treatment schedule (i.p. injection of 0.1 and 1 g/kg/day for 15 days). The acquisition and extinction of active avoidance behaviour were studied in a pole-jumping test situation. The retention of passive avoidance response was examined in a step-through passive avoidance task. PCA facilitated the rate of acquisition of pole-jumping response, and inhibited the extinction of the response. The dose of 1 g/kg was more potent than 0.1 g/kg in this respect. Also in the passive avoidance task, the treatment with PCA was followed by an improvement of avoidance retention. These results indicate that PCA is a behaviourally active compound in that it improves learning and memory capacities in old rat.

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Aging Animals Avoidance Learning Injections, Intraperitoneal Male Memory Pyrrolidinones Pyrrolidonecarboxylic Acid Rats Rats, Inbred Strains Journal Article

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F Drago, C Valerio, V D'Agata, C Astuto, F Spadaro, G Continella, U Scapagnini. Pyroglutamic acid improves learning and memory capacities in old rats.. https://pubmed.ncbi.nlm.nih.gov/3402813/

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