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Protein comparison and classification: a differential geometric approach.

S Rackovsky·D A Goldstein
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Abstract

A method is proposed for rapidly, quantitatively comparing protein structures of arbitrary sizes, based on the differential geometric representation. The method is applied to a group of 22 protein x-ray structures, and the resulting network of closest relationships is delineated. Several well-known fold types are automatically detected as groupings of related structures, even when the constituent proteins are of different lengths. A complete gradation of types is shown to be detected, ranging from all-helical to all-beta-structure proteins. A relationship among functionally similar proteins is shown in several cases, even where their three-dimensional structures differ. It is suggested that the positions of proteins within the network of relationships correspond with their folding mechanisms.

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Protein ConformationProteinsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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S Rackovsky, D A Goldstein. 1988. Protein comparison and classification: a differential geometric approach.. https://doi.org/10.1073/pnas.85.3.777

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