Long-term potentiation induced by physiologically relevant stimulus patterns.

G Buzsáki; H L Haas; E G Anderson

doi:10.1016/0006-8993(87)91618-0

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Long-term potentiation induced by physiologically relevant stimulus patterns.

G Buzsáki·H L Haas·E G Anderson

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Abstract

Single pulse stimuli were delivered to the Schaffer collaterals in the in vitro hippocampal slice preparation. Local application of bicuculline to the CA3 region resulted in a series of population cell bursts in CA3, resembling the neuronal patterns which occur in the normal, freely moving rat during hippocampal sharp waves. These bicuculline-induced cell bursts in CA3 resulted in long-term potentiation (LTP) of the CA1 response. These findings suggest that the naturally occurring hippocampal sharp waves may reflect events analogous to artificially induced LTP.

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Animals Bicuculline Electric Stimulation Hippocampus In Vitro Techniques Neurons Pyramidal Tracts Rats Journal Article

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G Buzsáki, H L Haas, E G Anderson. 1987-12-01. Long-term potentiation induced by physiologically relevant stimulus patterns.. https://doi.org/10.1016/0006-8993(87)91618-0

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