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Vancomycin entry into lung lymph in sheep.

D G May·C W Stratton·W D Denney·F L Watts·G R Bernard·R A Branch
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Abstract

The distribution of antibiotics into target tissues is a crucial factor in therapeutic efficacy. To estimate the availability of systemically administered vancomycin to the interstitial fluid in the lung, we have used a sheep model with a chronic pulmonary lymph fistula to collect simultaneously series of plasma and pulmonary lymph specimens during a 6-h period after an intravenous dose of vancomycin (7 mg/kg). After a minor delay in transit from blood to lymph, vancomycin was completely distributed to pulmonary lymph with a ratio of free drug in lymph to free drug in plasma of 0.9. This suggests that vancomycin is an excellent choice for treating pulmonary infections by susceptible organisms.

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AnimalsBlood ProteinsFemaleLungLymphPermeabilityProtein BindingSheepVancomycinJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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D G May, C W Stratton, W D Denney, F L Watts, G R Bernard, R A Branch. 1987. Vancomycin entry into lung lymph in sheep.. https://doi.org/10.1128/aac.31.11.1689

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