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PubMed · 3435561

A microelectronic conductimetric biosensor.

L D Watson·P Maynard·D C Cullen·R S Sethi·J Brettle·C R Lowe
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Abstract

The fabrication and operation of a microelectronic conductimetric biosensor is described. The device monitors the change in solution conductance occasioned by the catalytic action of enzymes immobilised over a planar conductance cell comprising serpentined and interdigitated metal conductor tracks. The output of the instrument was linear over a 3 min period on addition of urea to a sample cell overlaid with immobilised urease. The responses to any given urea concentration were reproducible to within approximately +/- 1%. The device responds to urea present in serum samples.

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ElectrochemistryEnzymes, ImmobilizedMicrochemistryUreaUreaseJournal ArticleResearch Support, Non-U.S. Gov't

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L D Watson, P Maynard, D C Cullen, R S Sethi, J Brettle, C R Lowe. A microelectronic conductimetric biosensor.. https://doi.org/10.1016/s0265-928x(87)80003-2

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