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PubMed · 34372

[French Society of Pediatrics, October 1977 (proceedings)].

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1978. [French Society of Pediatrics, October 1977 (proceedings)].. https://pubmed.ncbi.nlm.nih.gov/34372/

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[Beta-receptor blocking drugs and the bronchial system. A comparative study of pindolol and metoprolol (author's transl)].

Effects of the beta 2-receptor stimulating drug fenoterol were investigated after administration of beta-receptor blocking agents in 12 patients with obstructive respiratory disease and a hyperreactive bronchial system (positive acetylcholine test). In a double blind trial pindolol (universal beta-receptor blocking drug) and metoprolol (a cardioselective substance) were compared after administration of equally effective doses of 5 and 100 mg respectively. Whole-body plethysmography showed that both beta-receptor blocking drugs caused no bronchial constriction; the bronchodilating effects of fenoterol were not reduced. These findings must cast doubt on the differentiation between cardioselective and non-cardioselective beta-receptor blocking agents as far as practical therapeutic implications are concerned.

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