PubMed · 34445
The analysis of terbutaline in biological fluids by gas chromatography electron impace mass spectrometry.
Abstract
A highly sensitive and specific assay is described for the bronchodilator drug terbutaline in human plasma and urine, based on single ion monitoring gas chromatography mass spectrometry and employing a homologue of the drug as internal standard. Recovery of terbutaline and internal standard into ethyl acetate is effected at pH 9.8, while back-extraction into dilute acid serves to purify the initial extract. Following preparation of O-TMS, N-TFA derivatives, the drug and its homologue are detected by selected ion monitoring of their common base ion at m/e 355. The limit of detection of terbutaline by this procedure is 0.3 ng ml-1 from a 4 ml sample of plasma.
Explore related subjects
Keep this discovery
Explore connections, maps & timelines
R A Clare, D S Davies, T A Baillie. 1979. The analysis of terbutaline in biological fluids by gas chromatography electron impace mass spectrometry.. https://doi.org/10.1002/bms.1200060108
Cite the original work for its findings. Save a collection to share your selection of sources.