Behavioral trait associated with conditioned immunity.

R M Gorczynski; M Kennedy

doi:10.1016/0889-1591(87)90008-0

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Behavioral trait associated with conditioned immunity.

R M Gorczynski·M Kennedy

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Abstract

Inbred strains of mice were tested for their activity in an open field. Animals selected for high or low activity ("tails" of the normal distribution) were further inbred through nine generations (brother x sister) with further selection at each generation. Reciprocal skin grafts between the two groups were performed to ensure that little/no genetic drift occurred. Using a cyclophosphamide:saccharin conditioning paradigm (R. Ader & N. Cohen (1975) Psychosom. Med. 37, 333-342) we show that mice preselected for high activity in an open field were those in which it was most easy to demonstrate conditioned immunosuppression. There was no difference in the conditionability of the two groups as assessed by taste aversion. By use of a cross-fostering design we conclude that immunological conditioning (in adult mice) can be affected by a characteristic of the nursing mother which is associated with activity in an open-field trial.

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Animals Antibody Formation Avoidance Learning Conditioning, Classical Cyclophosphamide Exploratory Behavior Fear Female Immune Tolerance Inbreeding Male Maternal Behavior Mice Mice, Inbred C57BL Saccharin Journal Article Research Support, Non-U.S. Gov't

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R M Gorczynski, M Kennedy. 1987. Behavioral trait associated with conditioned immunity.. https://doi.org/10.1016/0889-1591(87)90008-0

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