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A modified Chou and Fasman protein structure algorithm.

W W Ralph·T Webster·T F Smith
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Abstract

A FORTRAN program PRSTRC has been developed for protein secondary structure prediction, which is a modified Chou and Fasman (1978) analysis. This implementation carries out a running average of amino acid structure occurrence frequencies, utilizes a simple set of nucleation conditions, and allows user control over nucleation threshold and cutoff parameters. The algorithm includes prediction of the newly defined secondary structure elements: omega loops (1986). It also generates a charge distribution and hydropathy profile. Output includes a simple graphic display for a printer, or a CRT using color addition. Correct structures are predicted for T. dyscritum hemerythrin and the variable domain of mouse immunoglobin k-chain.

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AlgorithmsAmino Acid SequenceProtein ConformationSoftwareSoftware DesignJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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W W Ralph, T Webster, T F Smith. 1987. A modified Chou and Fasman protein structure algorithm.. https://doi.org/10.1093/bioinformatics%2F3.3.211

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