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Considerations for peptic ulcer trials.

H Glise·B Hallerbäck·A Oden
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Abstract

A drug trial concerned with peptic ulcer treatment has to be carefully planned to make possible a valid conclusion. Calculations of the number of patients required have to be made early. This depends upon factors such as: if the comparison is to be made between two active drugs or an active drug and a placebo, if the aim is to show that two treatments are almost equal or if a certain difference is expected, the number of groups to be compared, and if intermediate checks are to be made. Thus, from a few dozen patients up to several thousand may be needed. If a multicenter dosing is adopted, which is often necessary, the minimum number of patients required from each centre should be specified and a good reporting system has to be created. When presenting the results, it is preferable to calculate a confidence interval for the difference between the treatments--especially in small studies where the risk is false conclusions would otherwise be large.

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Clinical Trials as TopicHumansPeptic UlcerPlacebosRandom AllocationSampling StudiesStatistics as TopicComparative StudyJournal Article

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H Glise, B Hallerbäck, A Oden. 1987. Considerations for peptic ulcer trials.. https://doi.org/10.3109/00365528709090952

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