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Increase in thromboxane B2 and decrease in prostaglandin E2 and 6-keto-prostaglandin F1 alpha release into rat bronchoalveolar fluid as a consequence of cigarette smoking.

H Tanizawa·T Iwanaga·H H Tai
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Abstract

Rats were exposed to cigarette smoke once daily for 4 to 8 weeks. Bronchoalveolar lavage fluid was obtained from each animal and assayed for immunoreactive PGE2, TXB2 and 6-Keto-PGF1 alpha. Significant increase in TXB2 and decrease in PGE2 and 6-Keto-PGF1 a release into bronchoalveolar fluid as a consequence of cigarette smoking were observed. These changes of arachidonate metabolites in lung alveoli may account in part for bronchoconstriction induced by cigarette smoking.

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6-Ketoprostaglandin F1 alphaAnimalsDinoprostoneProstaglandins EPulmonary AlveoliRatsSmokingTherapeutic IrrigationThromboxane B2Time FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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H Tanizawa, T Iwanaga, H H Tai. 1987. Increase in thromboxane B2 and decrease in prostaglandin E2 and 6-keto-prostaglandin F1 alpha release into rat bronchoalveolar fluid as a consequence of cigarette smoking.. https://doi.org/10.1016/0262-1746(87)90163-6

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