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PubMed · 3487831

Transforming growth factor-beta: biological function and chemical structure.

M B Sporn·A B Roberts·L M Wakefield·R K Assoian
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Abstract

Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-beta and essentially all of them have specific receptors for this peptide. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.

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AnimalsCell DivisionEpidermal Growth FactorGenesHumansPeptidesPlatelet-Derived Growth FactorRatsTransforming Growth FactorsJournal Article

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M B Sporn, A B Roberts, L M Wakefield, R K Assoian. 1986-08-01. Transforming growth factor-beta: biological function and chemical structure.. https://doi.org/10.1126/science.3487831

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