Three-dimensional structure of interleukin-2.

B J Brandhuber; T Boone; W C Kenney; D B McKay

doi:10.1126/science.3500515

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PubMed · 3500515

Three-dimensional structure of interleukin-2.

B J Brandhuber·T Boone·W C Kenney·D B McKay

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Abstract

Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel alpha-helical tertiary structure that suggests one portion of the molecule forms a structural scaffold, which underlies the receptor binding facets of the molecule.

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Animals Interleukin-2 Mice Models, Molecular Protein Conformation Solvents X-Ray Diffraction Journal Article Research Support, U.S. Gov't, P.H.S.

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B J Brandhuber, T Boone, W C Kenney, D B McKay. 1987-12-18. Three-dimensional structure of interleukin-2.. https://doi.org/10.1126/science.3500515

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