Autooxidative degradation of implanted polyether polyurethane devices.

K Stokes; A Coury; P Urbanski

doi:10.1177/088532828600100302

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Autooxidative degradation of implanted polyether polyurethane devices.

K Stokes·A Coury·P Urbanski

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Abstract

While certain polyether polyurethanes have been shown to be biostable, undesirable interactions between polymer, the body environment and device can occur. For example, the corrosion products of metallic parts can cause relatively rapid autooxidation of polyether soft segments. This phenomenon was first demonstrated in our laboratories by immersing polyurethane test specimens in metal ion solutions of different oxidation potentials. Subsequently, the mechanism was reasonably duplicated by immersing Pellethane 2363-80A insulated cardiac pacing leads in 3%, 37 degrees C hydrogen peroxide. In vivo studies after 1 year show that corrosion products from pure Co and Fe produce the most rapid degradation of the polyurethane.

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Animals Biocompatible Materials Biopolymers Corrosion Electrodes, Implanted Humans Materials Testing Oxidation-Reduction Pacemaker, Artificial Polyurethanes Rabbits Stress, Mechanical Time Factors Journal Article Research Support, Non-U.S. Gov't

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K Stokes, A Coury, P Urbanski. 1987. Autooxidative degradation of implanted polyether polyurethane devices.. https://doi.org/10.1177/088532828600100302

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