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PubMed · 3512932

Hyperuricemia and gout.

D C German·E W Holmes
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Abstract

Gout is a clinical syndrome encompassing a group of metabolic diseases that are all characterized by abnormal uric acid metabolism. In its fullest form, gout is defined by: an increase in the serum urate concentration; characteristic, recurrent, acute arthritic attacks, with monosodium urate monohydrate crystals demonstrable in synovial fluid leukocytes; tophi, usually in and around joints of the extremities, composed of monosodium urate monohydrate deposits; renal disease, often accompanied by hypertension with glomerular, tubular, interstitial, and vascular involvement; and uric acid nephrolithiasis. Any combination of these manifestations may occur, although tophi and urate nephropathy rarely antedate gouty arthritis.

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Acute DiseaseAdultAllopurinolAnti-Inflammatory AgentsArthritisArthrographyCalcinosisChronic DiseaseColchicineFemaleGoutHumansKidney CalculiKidney DiseasesMiddle AgedProbenecidUric AcidJournal ArticleReview

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D C German, E W Holmes. 1986. Hyperuricemia and gout.. https://doi.org/10.1016/s0025-7125(16)30961-0

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