Insulin binding in denervated muscle.

D Donaldson; O B Evans; R W Harrison

doi:10.1002/mus.880090304

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Insulin binding in denervated muscle.

D Donaldson·O B Evans·R W Harrison

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Abstract

Insulin binding was measured in rat muscle following denervation. There was a 40% reduction in the number of high-affinity insulin receptors, with no change in the insulin binding Kd. Selected muscles showed a 40%-60% reduction in weight during this period. The down-regulation in the number of insulin receptors may contribute to the mechanism of muscle atrophy following denervation.

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Animals Cell Fractionation Cell Membrane Insulin Kinetics Male Muscle Denervation Muscles Rats Rats, Inbred Strains Receptor, Insulin Journal Article Research Support, Non-U.S. Gov't

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D Donaldson, O B Evans, R W Harrison. Insulin binding in denervated muscle.. https://doi.org/10.1002/mus.880090304

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