DNA adducts and cell cycle.

H M Rabes

doi:10.1007/bf00395911

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DNA adducts and cell cycle.

H M Rabes

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Abstract

Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-related genes replicating at critical phases of DNA synthesis, or cell cycle-related differences in the repair of DNA adducts. Some recent data on these subjects are summarized, mainly in context of cell cycle-dependent transformation sensitivity of regenerating rat liver.

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Animals Carcinogens Cell Cycle Cell Transformation, Neoplastic DNA DNA Repair DNA Replication Liver Regeneration Journal Article Research Support, Non-U.S. Gov't Review

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H M Rabes. 1986. DNA adducts and cell cycle.. https://doi.org/10.1007/bf00395911

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