Cell-cell interaction and carcinogenesis.

H Yamasaki

doi:10.1177/019262338601400313

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Cell-cell interaction and carcinogenesis.

H Yamasaki

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Abstract

Before carcinogenic stimuli are introduced, a potentially cancerous cell functions normally; growth is controlled and the cell exists in complete harmony with that of surrounding cells in a given tissue. During the process of multi-stage carcinogenesis, such harmony is destroyed and a presumptive initiated cell accomplishes a clonal expansion, neglecting the growth pattern of surrounding normal cells. Recent results from our own laboratory and others strongly suggest that blocked gap-junctional intercellular communication is an important determinant during the process of tumor promotion.

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Animals Binding Sites Carcinogens Cell Communication Cell Transformation, Neoplastic Cells, Cultured Humans Intercellular Junctions Phorbol Esters Protein Kinase C Journal Article Research Support, U.S. Gov't, P.H.S.Review

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H Yamasaki. 1986. Cell-cell interaction and carcinogenesis.. https://doi.org/10.1177/019262338601400313

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