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Decrease in number of hippocampal gamma-aminobutyric acid (GABA) immunoreactive cells in the rat kindling model of epilepsy.

W Kamphuis·W J Wadman·R M Buijs·F H Lopes da Silva
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Abstract

Daily repeated tetanic electrical stimulation (kindling) of hippocampus or other brain structures leads to progressive increase in epileptiform activity. Since kindling may involve changes in the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), the distribution of this amino acid was studied. A significant decrease in number of GABA immunoreactive positive cell bodies in stimulated CA1 region of the rat hippocampus compared to the contralateral side was found.

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AnimalsHippocampusImmunoenzyme TechniquesKindling, NeurologicMaleRatsRats, Inbred Strainsgamma-Aminobutyric AcidJournal ArticleResearch Support, Non-U.S. Gov't

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W Kamphuis, W J Wadman, R M Buijs, F H Lopes da Silva. 1986. Decrease in number of hippocampal gamma-aminobutyric acid (GABA) immunoreactive cells in the rat kindling model of epilepsy.. https://doi.org/10.1007/bf00340486

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