PubMed · 3544987
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T J Witek, E N Schachter. 1987. Methacholine availability for bronchial challenge testing.. https://doi.org/10.1164/arrd.1987.135.2.514
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Research on occupational lung disease has been a growing challenge over the past 4 decades. Exposure to respiratory toxins has increased in many industrializing countries of the world while new and old hazards continue to exist in the industrialized world. The focus of this paper is on measurement tools commonly used in the study of occupational lung diseases. The emphasis is on epidemiology, a discipline which has contributed to the understanding and control of occupational lung disease. An examination of these tools reveals that (1) there are more commonalities than contrasts in available methods; (2) researchers in industrializing settings can contribute much to our understanding of occupational lung diseases; (3) international collaboration is needed in refining measurement tools; and (4) international collaboration should proceed on studies of preventive strategies.
A female dentist specialized in orthodontics repeatedly developed symptoms of pharyngitis at work. A chamber provocation test indicated that her symptoms were caused by acrylics. Prick tests with acrylics were negative, while patch tests were strongly positive although the patient had no skin symptoms. The relationship between the symptoms and the patch test results is discussed. It is suggested that type IV allergic reactions may be involved in symptoms of the upper respiratory tract.
A severe attack of farmer's lung developed in a dairy farmer after a workplace challenge. The patient showed full recovery after corticosteroid therapy. If a workplace challenge is considered necessary in the diagnosis of farmer's lung, care should be taken to avoid unnecessarily heavy exposure to the offending antigens.