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PubMed · 3549871

Hyperactivity and methylphenidate: rate-dependent effects on attention.

M D Rapport·G J DuPaul
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Abstract

The behavioral effects of CNS stimulants on attention deficit disorder (hyperactive) children's attention are inversely related to their pre-drug rate of behavior, i.e. the effects are rate-dependent. The strength and shape of this relationship are affected by dose and the child's unique reaction to the drug, yet appear unrelated to body weight. Dosage should be directly manipulated in pediatric psychopharmacological studies and the practice of using mg/kg dosage schedules may no longer be necessary.

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AttentionAttention Deficit Disorder with HyperactivityChildChild BehaviorClinical Trials as TopicDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMethylphenidateClinical TrialJournal ArticleRandomized Controlled Trial

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BibTeXRIS

M D Rapport, G J DuPaul. 1986. Hyperactivity and methylphenidate: rate-dependent effects on attention.. https://doi.org/10.1097/00004850-198601000-00006

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